The relationship between endogenous serum insulin concentration and glucose uptake in the forearm muscles of nondiabetics.
نویسندگان
چکیده
IN A SERIES OF EXPERIMENTS ON THE HUMAN FOREARM, PREPARATION DESIGNED TO EXAMINE THE EFFECTS OF VARIATIONS IN IMMUNOLOGICALLY DETERMINED ENDOGENOUS SERUM INSULIN LEVELS AND OF BLOOD GLUCOSE CONCENTRATIONS ON MUSCULAR GLUCOSE UPTAKE, THE FOLLOWING RESULTS WERE OBTAINED: (a) A highly significant correlation between muscular glucose uptake and simultaneous arterial serum insulin concentration. (b) No correlation between glucose uptake and simultaneous arterial blood glucose concentration during hyperglycemia. (c) A maximal insulin effect on muscular glucose uptake at arterial serum insulin concentrations at about 200 muU/ml. This observation is, however, based on only a few experiments.
منابع مشابه
Uptake in the Forearm Muscles of Nondiabetics
A B S T R A C T In a series of experiments on the human forearm, preparation designed to examine the effects of variations in immunologically determined endogenous serum insulin levels and of blood glucose concentrations on nMtuscular glucose uptake, the following results were obtained: (a) A highly significant correlation between muscular glucose uptake and simultaneous arterial serum insulin ...
متن کاملThe relationship between serum level of 25- hydroxy vitamin D with anthropometric indices and some biochemical parameters in obese women
Background : Some studies have shown that the serum concentration of 25- hydroxy vitamin D which is represent the status of body vitamin D, has a diverse relationship with obesity status, and the risk of obesity decreases in people with high level of 25- hydroxy vitamin D. The aim of this study is to investigate the correlation between the serum level of 25- hydroxy vitamin D and anthropometric...
متن کاملGhrelin associate determinative markers of fasting blood glucose in none diabetic healthy obese males
Introduction: Ghrelin, a gut neuropeptide, plays an important role in appetite, food intake and weight regulation. The aim of the present study was to determine serum ghrelin in relation to fasting glucose concentration and effective markers in glucose level (insulin, insulin resistance, beta- cell function) in none-diabetic obese males. Methods: We studied the baseline glucose, serum insulin a...
متن کاملEffect of Very Small Concentrations of Insulin on Forearm Metabolism. Persistence of Its Action on Potassium and Free Fatty Acids without Its Effect on Glucose.
When insulin is infused into a brachial artery of normal men at a constant rate of 100 uU per minute per kg of body weight, there appears rapidly evidence of increased glucose uptake by forearm muscles and by forearm adipose tissue, a shift from net potassium loss to potassium uptake by muscle, increased K uptake by adipose tissue, and marked decrease in release of free fatty acids (FFA) by for...
متن کاملConjugated linoleic acid supplementation enhances insulin sensitivity and peroxisome proliferator-activated receptor gamma and glucose transporter type 4 protein expression in the skeletal muscles of rats during endurance exercise
Objective(s):This study examined whether conjugated linoleic acid (CLA) supplementation affects insulin sensitivity and peroxisome proliferator-activated receptor gamma (PPAR-γ) and glucose transporter type 4 (GLUT-4) protein expressions in the skeletal muscles of rats during endurance exercise. Materials and Methods:Sprague-Dawley male rats were randomly divided into HS (high-fat diet (HFD) s...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- The Journal of clinical investigation
دوره 47 6 شماره
صفحات -
تاریخ انتشار 1968